Chicken chronic respiratory disease (CRD) is a common and frequently occurring disease in chickens. It is an infectious disease caused by Mycoplasma gallisepticum (mg), which seriously threatens the chicken industry. Chicken flocks are infected with Mycoplasma alone and have respiratory symptoms, but do not cause death. The disease is not divided into age and season, but in the cold and changeable seasons, the incidence is high. This disease is often complicated or secondary to other bacterial or viral diseases. At present, the probability of secondary viral diseases caused by this disease is very high, especially the high probability of secondary Newcastle disease and mild influenza, which often brings great economic losses, so we should attach great importance to it at present.

Prevention of Mycoplasma gallisepticum

At present, the prevention of chronic respiratory diseases in chickens is generally not good, only some breeding farms are using Mycoplasma gallisepticum vaccine. This disease is a common epidemic disease, and has a great relationship with seasons, daily management of farms, feed, etc., especially when the temperature changes, the temperature difference between day and night is large, and the ventilation is not good, the disease is easy to occur. At present, the treatment of this disease is still given priority to.

Drug treatment of Mycoplasma gallisepticum

At present, when farmers find chronic respiratory diseases, they usually give priority to clinical symptoms, and some of them are more complete, which leads to not only Mycoplasma gallisepticum infection, but also a high probability of mixed infection of bacterial diseases such as Chicken Escherichia coli and Salmonella. We should cooperate with the use of some antibacterial drugs in the treatment. The treatment of this disease is mainly with macrolide drugs for drinking water or mixing materials, mainly tylosin, roxithromycin, tamoxigenin and tilmicosin. However, the clinical effect of single use of the above drugs is not very ideal, and the cost is high. At present, tilmicosin is the most effective drug, but it can not be used alone. The results showed that the combination of tilmicosin and enrofloxacin had the best antibacterial effect on Mycoplasma gallisepticum. In clinical application, tilmicosin and enrofloxacin have good compatibility effect. Enrofloxacin can kill mycoplasma, regulate water, electrolyte and acid-base balance in the body, improve blood concentration, increase blood glucose concentration, supply energy to the body, prevent and alleviate the accumulation of toxins, and make the body return to normal.

In the treatment of Mycoplasma gallisepticum, some other prescriptions are still used in clinic, such as doxycycline + tylosin + Shuanghuanglian, roxithromycin + lincomycin + Shuanghuanglian. The effect of combined medication is better, and some compound Chinese medicine for relieving cough and resolving phlegm can also be used in traditional Chinese medicine. Reasonable combination of Chinese and Western medicine can be used

High efficacy, reduce drug resistance.

Reducing drug resistance

Mycoplasma gallisepticum is easy to produce drug resistance, which increases the difficulty of treatment. Especially when single drug use, it is easy to produce drug resistance. At present, it is recommended to combine drugs or add some traditional Chinese medicine in clinical treatment, which can effectively reduce the occurrence of drug resistance. In frequent areas, do not often use the same prescription drugs, several effective prescriptions used in rotation, this will also reduce drug resistance. In the frequent occurrence areas, before treatment, the best drug should be found out through laboratory in vitro antibacterial test, which is the most effective method to reduce the drug resistance of Mycoplasma gallisepticum. However, due to the different breeding conditions in different areas, many areas can not achieve laboratory antibacterial.

Rational prevention of Mycoplasma gallisepticum

Due to the harm caused by Mycoplasma gallisepticum disease and the susceptibility to drug resistance during treatment, the disease should be mainly prevented, and the principle of "self propagation and self-cultivation" should be adhered to; the feeding mode of "all in all out" should be implemented; the feeding management should be strengthened, Pay attention to disinfection work, at present, after treatment of this disease in many areas, there will be repeated, which is caused by poor control of feed environment and not timely disinfection. At ordinary times, it is necessary to strengthen the feeding management and eliminate the inducing factors

Mycoplasma infection or mixed infection with other pathogens is one of the important measures.

The age difference of Mycoplasma gallisepticum was not obvious in chicken flocks. Chickens of all ages from brooding to laying eggs could be infected with Mycoplasma gallisepticum. According to the epidemiological survey in the past two years, the incidence of chicken infection is gradually increasing, especially for chickens within 20 days of age, the incidence of Mycoplasma gallisepticum can be reduced by using drugs in advance at the age when chickens are prone to occur. Strengthen the management of chicken house in cold and changeable seasons.

5 Conclusion

In the breeding industry, Mycoplasma gallisepticum disease often does not cause people‘s attention, but the harm of this disease is really huge. This disease often coexists with other bacterial or viral diseases or secondary, especially secondary Newcastle disease and mild influenza, which brings serious harm to the breeding industry. If the anal chickens get up early to be infected with Mycoplasma gallisepticum, it is not easy to be found. At this time, when inoculated with other vaccines, such as Newcastle disease, infectious laryngotracheal vaccine, H9 vaccine and so on, the death phenomenon will often occur, which will inhibit the production of vaccine antibody, which will easily lead to the occurrence of other diseases. Therefore, Mycoplasma gallisepticum disease is a great harm to the breeding industry. For this disease, we suggest that we should focus on prevention and strengthen feeding management. When this disease occurs, we should find out early and treat it early. We should use reasonable combination of drugs and treat it as soon as possible to avoid the secondary of other diseases and reduce the loss. Jingjing of Mycoplasma gallisepticum